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KMID : 0043319940170030161
Archives of Pharmacal Research
1994 Volume.17 No. 3 p.161 ~ p.165
Synthesis of (¡¾)-trans-6-[2-(benzotriazolyl)ethyl]tetrahydro-4-hydroxy-2H-pyran-2-ones as Potential HMG-CoA Reductase Inhibitors
Kim Jin-Il

Lee Soo-Kyung
Jahng Yurng-Dong
Abstract
New hypolipaemic agents, in which benzotriazole moiety is connected to tetrahydro-4-hydroxy-2H-pyran-2-one by a two-carbon bridge, were designed and synthesized to show sinificant cholesterol-lowering effect comparable to mevinolin.
KEYWORD
Hypolipaemic Agent, HMG-CoA reductase inhibitor, Benzotriazole
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